Chapter 1 Background and History
1．1 Background
1．2 History
1．3 The place of genetics in medicine
Chapter 2 Human Gene and Human Genome
2．1 A brief history of DNA：the hereditary material
2．2 DNA structure and function
2．3 The structure and function of genes
2．4 The features of genomes
2．5 Genome maps
Chapter 3 Genetic Variation
3．1 Introduction
3．2 The chemical basis of genetic mutation
3．3 Types of genetic mutation
3．4 Description of genetic mutation
3．5 Mutagenic factors
3．6 Factors affecting human genetic mutation
Chapter 4 Autosomal Dominant and Recessive Inheritance
4．1 Introduction
4．2 Pedigree and pedigree analysis
4．3 Autosomal dominant inheritance
4．4 Autosome recessive disease
4．5 Clinical examples
Chapter 5 Sex-Linked Modes of Inheritance
5．1 Introduction
5．2 Sex chromosomes
5．3 Sex-linked modes of inheritance '
5．4 X chromosome inactivation and lyon hypothesis
Chapter 6 Clinical Cytogenetics：the Chromosomal Basis of Human Disease
6．1 Chromosome
6．2 Chromosome analysis
6．3 Chromosome abnormalities
6．4 Clinical examples
Chapter 7 Mitochondrial Inheritance and Mitochondrial Diseases
7．1 Mitochondrial genome
7．2 Mitoehondrial inheritance
7．3 Mitochondrial diseases
Chapter 8 Polygenic Inheritance and Polygenic Diseases
8．1 Genetics of quantitative traits
8．2 Polygenic diseases
8．3 Recurrence risk of polygenie diseases
8．4 Research progress in polygenie genetic diseases
Chapter 9 Birth Defect
9．1 Congenital abnormalities
9．2 The clinical characteristics of birth defects
9．3 Prevention of birth defects
Chapter 10 Cancer Genetics
10．1 The genetic basis of Oncology
10．2 Oncogene
10．3 Tumor suppressor genes
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