药用高分子材料

Chapter 1. Introduction to Pharmaceutical Excipients
药用辅料概述 1
1.1 Definition of pharmaceutical excipients 1
1.2 What are excipients doing in medicines? 2
1.3 Quality and safty of excipients 3
1.4 Relationship between polymers and pharmaceutical excipients 5
1.5 Specific notes for polymers used in drug delivery system 6
本章中文导读 7
References 9
Chapter 2. Introduction to Polymers
高分子材料概述 10
2.1 What are polymers? 10
2.2 Polymer structure and morphology 11
2.2.1 Molecular weight 11
2.2.2 Configuration and conformation 12
2.2.3 Chain structure 14
2.2.4 Crystalline 15
2.3 Synthesis 17
2.3.1 Addition polymerization 17
2.3.2 Condensation polymerization 19
2.3.3 Cross-linking reaction 19
2.4 Characteristic properties of polymers 20
2.4.1 Thermal properties 20
2.4.2 Mechanical properties 22
2.4.3 Viscoelastic properties 23
2.5 Characterization techniques 23
2.5.1 Determination of molecular weight 23
2.5.2 Determination of structure 24
2.5.3 Differential scanning calorimetry 25
2.6 Fabrication and processing 26
2.6.1 Injection molding 27
2.6.2 Extrusion 27
2.6.3 Spinning 27
本章中文导读 28
References 32
Chapter 3. Natural Polymers as Pharmaceutical Excipients
天然来源的药用高分子辅料 33
3.1 Starch and its derivates 33
3.1.1 Starch 33
3.1.2 Pregelatinized starch 36
3.1.3 Dextrin 37
3.1.4 Cyclodextrin 39
3.1.5 Sodium carboxymethyl starch 42
本节中文导读 44
3.2 Cellulose and its derivates 46
3.2.1 Microcrystalline cellulose 46
3.2.2 Powdered cellulose 47
3.2.3 Methylcellulose 48
3.2.4 Ethylcellulose 50
3.2.5 Hydroxyethyl cellulose 52
3.2.6 Hydroxypropyl cellulose 54
3.2.7 Hydroxypropyl methylcellulose 56
3.2.8 Carboxymethylcellulose sodium 59
3.2.9 Carboxymethylcellulose calcium 60
3.2.10 Cellulose acetate phthalate 61
本节中文导读 63
3.3 Other natural polymers in pharmaceutics 66
3.3.1 Chitin/chitosan 66
3.3.2 Alginate and sodium/calcium alginate 68
3.3.3 Acacia 71
3.3.4 Xanthan gum 72
3.3.5 Gelatin 74
3.3.6 Albumin 76
本节中文导读 78
References 80
Chapter 4. Synthetic Polymers as Pharmaceutical Excipients
合成的药用高分子敷料 81
4.1 Polymers based on polyvinyl 81
4.1.1 Polyvinyl alcohol 81
4.1.2 Polymethacrylates 83
4.1.3 Polyvinylpyrrolidone (Povidone) 87
4.1.4 Crospovidone 89
4.1.5 Carbomer 90
本节中文导读 93
4.2 Polymers based on polyether 95
4.2.1 Polyethylene glycol 95
4.2.2 Poloxamer 99
4.2.3 Polysorbates 102
本节中文导读 105
References 106
Chapter 5. Novel Synthetic Biodegradable Polymers as Drug
Delivery Carrier
新型可生物降解的合成药用高分子材料 107
5.1 Introduction 107
5.2 Polymers based on polyester 108
5.2.1 Poly(lactic acid) and poly(lactic-co-glycolic acid) copolymers 108
5.2.2 Polycaprolactone 111
5.2.3 Poly(β-hydroxybutyrate) 112
5.3 Other biodegradable polymers 113
5.3.1 Poly(orthoesters) 113
5.3.2 Poly(phosphate esters) 115
5.3.3 Polyanhydrides 116
5.3.4 Poly(amino acids) 117
5.3.5 Polyphosphazenes 119
本章中文导读 121
References 124
Chapter 6. Advanced Applications of Functional Polymer in Drug Delivery
功能高分子材料在药物输送中的应用进展 125
6.1 Hydrogels for pharmaceutical application 125
6.1.1 Introduction 125
6.1.2 Preparation of hydrogels 126
6.1.3 Properties of hydrogels 127
6.1.4 Pharmaceutical applications of hydrogels 129
本节中文导读 133
6.2 Polymer-based nanomedicine and self-assemblying polymers 134
6.2.1 Introduction to nanomedicine 134
6.2.2 Micellation of self-assemblying polymers 134
6.2.3 Biological significance of polymeric micelles 136
6.2.4 Drug release from polymeric micelles 137
6.2.5 Examples of polymeric micelles for drug delivery 138
本节中文导读 141
6.3 Polymer-drug conjugates 142
6.3.1 Introduction 142
6.3.2 Design and development of polymer-drug conjugates 144
6.3.3 Examples for polymer-drug conjugates 146
本节中文导读 152
6.4 Polymers for gene delivery 153
6.4.1 Introduction to gene delivery 153
6.4.2 Polymeric vectors 154
本节中文导读 161
References 162